361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study introduces a quantitative single-molecule mapping toolkit to reveal that right ventricular failure drives spatially heterogeneous remodeling of RyR2-JPH2 nanodomains, which alters local stoichiometry and cell-wide organization to dysregulate calcium signaling and promote spontaneous calcium waves.
This study identifies a conserved mechanism in *Schizosaccharomyces pombe* where domain-specific receptors, such as the nucleolar protein Dnt1, interact with a specific surface on the cohesin loader Scc4/Ssl3 to direct targeted cohesin loading, thereby organizing specialized chromosomal domains like centromeres and rDNA through loop extrusion without disrupting global chromosome architecture.
This study demonstrates that heparan sulfate chains orchestrate the nanoscale organization and dynamics of Glypican-3 on hepatoma cells, facilitating the assembly of GPC3-Wnt receptor complexes to drive efficient Wnt/-catenin signaling.
This study reveals that the Dip2-Pkc1 signaling axis maintains mitochondrial integrity in eukaryotes by utilizing a specific lipid acyl code of diacylglycerols to recruit Pkc1 to mitochondria, thereby regulating organelle morphology and function during respiratory growth.
This study demonstrates that domestic sheep can serve as a host for generating donor-derived kidneys by using SALL1-null, xenoantigen-free embryos and restoring organogenesis through morula complementation with donor cells, thereby establishing a new proof-of-concept model for in vivo human organ generation.
This study utilizes CRISPR-Cas9 knockout and mass spectrometry in Neuro-2a cells to identify KIF5A and KIF18B as novel kinesin targets of KIFBP, revealing how this protein regulates cytoskeletal dynamics and neurite extension during neuronal development.
This paper presents a deep attention network-based model and an accompanying interpretability toolkit that accurately infer and visualize the specific rules governing cell-cell interaction dynamics directly from trajectory data, without requiring prior assumptions about biological mechanisms.
This study identifies and characterizes LmME2 as the first cytosolic malic enzyme in *Leishmania major*, demonstrating that its loss disrupts pyridine nucleotide homeostasis and redox balance, thereby impairing parasite survival and virulence and highlighting it as a promising drug target.
This study demonstrates that human iPSC-derived hematopoietic stem cells retain a sustained, youthful epigenetic identity and restored telomere length across differentiation and serial transplantation, independent of donor age, thereby establishing a framework for regenerative medicine applications.
This study demonstrates that p70S6 kinase phosphorylates the AP2 μ2 subunit at serine 45 to facilitate clathrin-mediated endocytosis by modulating the conformational dynamics of the AP2 complex, thereby enhancing the internalization of key cell-surface receptors.